Decline of EMRSA-16 amongst methicillin-resistant Staphylococcus aureus causing bacteraemias in the UK between 2001 and 2007

Objectives Between 1998 and 2000, 95.6% of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemias in the UK were due to two epidemic strains, namely EMRSA-15 or EMRSA-16 (60.2% and 35.4%, respectively). We sought to determine the proportions of these strains before and after the general dec...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2010-03, Vol.65 (3), p.446-448
Main Authors: Ellington, Matthew J., Hope, Russell, Livermore, David M., Kearns, Angela M., Henderson, Katherine, Cookson, Barry D., Pearson, Andrew, Johnson, Alan P.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteremia - epidemiology
Bacteremia - microbiology
Bacteria
Bacterial diseases
Bacterial sepsis
Bacterial Typing Techniques
Biological and medical sciences
Blood
bloodstream infections
DNA Fingerprinting
Drug resistance
Epidemics
Genotype
Human bacterial diseases
Incidence
Infectious diseases
Medical sciences
Methicillin-Resistant Staphylococcus aureus - classification
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Microbial Sensitivity Tests
Molecular Epidemiology
MRSA
Pathology
Pharmacology. Drug treatments
Polymerase Chain Reaction
Sequence Analysis, DNA
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Staphylococcus infections
surveillance
United Kingdom - epidemiology
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Summary:Objectives Between 1998 and 2000, 95.6% of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemias in the UK were due to two epidemic strains, namely EMRSA-15 or EMRSA-16 (60.2% and 35.4%, respectively). We sought to determine the proportions of these strains before and after the general decline in MRSA bacteraemia that began around 2004. Methods Consecutive MRSA isolates collected in 2001, 2003, 2005 and 2007 by the BSAC Bacteraemia Surveillance Programme were categorized to multilocus sequence typing (MLST) clonal complex and to SCCmec type by PCR. MICs were determined by the BSAC method. Data trends were tested for significance using a generalized linear regression model. Results Collectively, EMRSA-15 and EMRSA-16 consistently accounted for ∼95% of MRSA studied between 2001 and 2007, but the proportions of EMRSA-16 declined from 21.4% in 2001 to 9% in 2007 (P 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkp448