Evolution of a multifunctional gene: The warm temperature acclimation protein Wap65 in the European seabass Dicentrarchus labrax

The warm temperature acclimation protein Wap65 has been shown to be involved in temperature acclimation, in immune response as well as in development. In teleosts, two types of Wap65 proteins, Wap65-1 and Wap65-2 are found, both acting as a multifunctional agent in several biological processes. In t...

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Bibliographic Details
Published in:Molecular phylogenetics and evolution 2010-05, Vol.55 (2), p.640-649
Main Authors: Sarropoulou, Elena, Fernandes, Jorge M.O., Mitter, Karin, Magoulas, Antonios, Mulero, Victoriano, Sepulcre, Maria P., Figueras, Antonio, Novoa, Beatriz, Kotoulas, Georgios
Format: Article
Language:English
Subjects:
Acclimation
Acclimatization - genetics
Adaptation
Animals
Bass - classification
Bass - genetics
Bass - growth & development
Biological
Development
Differential expression
DNA, Complementary - genetics
Evolution
Evolution, Molecular
Evolutionary
Fish Proteins - genetics
Gene evolution
Gene Expression Regulation, Developmental
Genes
Hemopexin - analogs & derivatives
Hemopexin - genetics
Infection
Pathogens
Phylogeny
Positive selection
Proteins
Selection, Genetic
Sequence Analysis, DNA
Teleost
Temperature
Wap65
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Summary:The warm temperature acclimation protein Wap65 has been shown to be involved in temperature acclimation, in immune response as well as in development. In teleosts, two types of Wap65 proteins, Wap65-1 and Wap65-2 are found, both acting as a multifunctional agent in several biological processes. In the present study we identified both transcripts Wap65-1 and Wap65-2 for the European seabass ( Dicentrarchus labrax), examined their evolutionary rate and performed selection tests. The two paralogues were shown to be under moderate positive selection indicating their evolutionary adaptation. This functional diversification was further explored through expression studies. Both transcripts were differentially expressed during development as well as in various tissues and pathogen challenges, showing that Wap65-1 and Wap65-2 have evolved diverse functions. These results direct to the hypothesis that Wap65 proteins may, similarly to heat-shock proteins, have a general role in cell physiology.
ISSN:1055-7903
1095-9513
DOI:10.1016/j.ympev.2009.10.001