Transforming growth factor beta receptor II (TGFBR2) polymorphisms and the association with nonsegmental vitiligo in the Korean population

Summary The precise cause of vitiligo is unknown. However, autoimmunity is considered the most likely aetiology, especially in nonsegmental vitiligo (NSV). In this study we determined whether or not the transforming growth factor beta receptor II (TGFBR2) gene contributes to susceptibility for NSV i...

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Published in:International journal of immunogenetics 2010-08, Vol.37 (4), p.289-291
Main Authors: Yun, J. Y., Uhm, Y. K., Kim, H. J., Lim, S. H., Chung, J.-H., Shin, M.-k., Yim, S.-V., Lee, M.-H.
Format: Article
Language:English
Subjects:
Adult
Autoimmune Diseases - epidemiology
Autoimmune Diseases - genetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Protein-Serine-Threonine Kinases - genetics
Receptors, Transforming Growth Factor beta - genetics
Republic of Korea - epidemiology
Vitiligo - epidemiology
Vitiligo - genetics
Vitiligo - immunology
Young Adult
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container_title International journal of immunogenetics
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creator Yun, J. Y.
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description Summary The precise cause of vitiligo is unknown. However, autoimmunity is considered the most likely aetiology, especially in nonsegmental vitiligo (NSV). In this study we determined whether or not the transforming growth factor beta receptor II (TGFBR2) gene contributes to susceptibility for NSV in the Korean population. Blood samples were collected from 415 controls and 233 cases. We selected three single nucleotide polymorphisms (SNPs) in the TGFBR2 gene. The genotypes of the SNPs were determined using direct sequencing. All of the SNPs were significantly different between the vitiligo patients and controls (rs2005061, co‐dominant, dominant, recessive, P 
doi_str_mv 10.1111/j.1744-313X.2010.00923.x
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All of the SNPs were significantly different between the vitiligo patients and controls (rs2005061, co‐dominant, dominant, recessive, P &lt; 0.05; rs3773645, co‐dominant, dominant, recessive, P &lt; 0.05; rs3773649, co‐dominant, recessive, P &lt; 0.05). In addition, haplotype 1 (CG) and haplotype 2 (GA) of the linkage disequilibrium (LD) block were also associated with a risk of NSV. 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source Wiley-Blackwell Read & Publish Collection
subjects Adult
Autoimmune Diseases - epidemiology
Autoimmune Diseases - genetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Protein-Serine-Threonine Kinases - genetics
Receptors, Transforming Growth Factor beta - genetics
Republic of Korea - epidemiology
Vitiligo - epidemiology
Vitiligo - genetics
Vitiligo - immunology
Young Adult
title Transforming growth factor beta receptor II (TGFBR2) polymorphisms and the association with nonsegmental vitiligo in the Korean population
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