Suppressive effects of a cyanine dye against herpes simplex virus (HSV)-1 infection

In this study, we demonstrate that a cyanine dye, lumin, significantly suppressed cytopathic effect by herpes simplex virus (HSV)-1 toward human amnionic FL cell and also it reduced replication of HSV-1 in a dose-dependent manner. In addition, lumin additively augmented the antiviral effect of inter...

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Bibliographic Details
Published in:Biomedical Research 2009, Vol.30(6), pp.365-368
Main Authors: Ushio, Chie, Ariyasu, Harumi, Ariyasu, Toshio, Arai, Shigeyuki, Ohta, Tsunetaka, Fukuda, Shigeharu
Format: Article
Language:English
Subjects:
Amniotic Fluid - cytology
Carbocyanines - pharmacology
Carbocyanines - therapeutic use
Cell Line
Endosomes - chemistry
Endosomes - drug effects
Herpes Simplex - drug therapy
Herpes simplex virus 1
Herpesvirus 1, Human - drug effects
Humans
Hydrogen-Ion Concentration
Interferon-alpha - pharmacology
Interferon-alpha - therapeutic use
Quinolinium Compounds - pharmacology
Quinolinium Compounds - therapeutic use
Virus Replication - drug effects
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Summary:In this study, we demonstrate that a cyanine dye, lumin, significantly suppressed cytopathic effect by herpes simplex virus (HSV)-1 toward human amnionic FL cell and also it reduced replication of HSV-1 in a dose-dependent manner. In addition, lumin additively augmented the antiviral effect of interferon (IFN)-α. Furthermore, fluorescence microscopic study showed that lumin (not IFN-α) itself remarkably induced alkalinization of intracellular organelle, suggesting the inhibition of virus invasion into the cells. These results suggest that lumin exerts an antiviral action against HSV-1 with the independent pathways of IFN-α and also it would become a therapeutically effective drug in clinical practice.
ISSN:0388-6107
1880-313X
DOI:10.2220/biomedres.30.365