winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster

The PEV-modifying winged-helix/forkhead domain transcription factor JUMU of Drosophila is an essential protein of pleiotropic function. The correct gene dose of jumu is required for nucleolar integrity and correct nucleolus function. Overexpression of jumu results in bloating of euchromatic chromoso...

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Bibliographic Details
Published in:Chromosome research 2010-04, Vol.18 (3), p.307-324
Main Authors: Hofmann, Annemarie, Brünner, Madeleine, Schwendemann, Alexander, Strödicke, Martin, Karberg, Sascha, Klebes, Ansgar, Saumweber, Harald, Korge, Günter
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Cell Biology
Cell Nucleolus - genetics
Cell Nucleolus - metabolism
Chromatin
Chromatin - metabolism
Chromosomes
Drosophila melanogaster
Drosophila melanogaster - growth & development
Drosophila melanogaster - metabolism
Drosophila Proteins - chemistry
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Gene expression
Human Genetics
Insects
Larva - metabolism
Life Sciences
Microscopy, Confocal
Molecular Sequence Data
Plant Genetics and Genomics
Protein Binding
Protein Transport
Proteins
Salivary Glands - cytology
Salivary Glands - metabolism
Transcription Factors - chemistry
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic
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Summary:The PEV-modifying winged-helix/forkhead domain transcription factor JUMU of Drosophila is an essential protein of pleiotropic function. The correct gene dose of jumu is required for nucleolar integrity and correct nucleolus function. Overexpression of jumu results in bloating of euchromatic chromosome arms, displacement of the JUMU protein from the chromocenter and the nucleolus, fragile weak points, and disrupted chromocenter of polytene chromosomes. Overexpression of the acidic C terminus of JUMU alone causes nucleolus disorganization. In addition, euchromatic genes are overexpressed and HP1, which normally accumulates in the pericentric heterochromatin and spreads into euchromatic chromosome arms, although H3-K9 di-methylation remains restricted to the pericentric heterochromatin. The human winged-helix nude gene shows similarities to jumu and its overexpression in Drosophila causes bristle mutations.
ISSN:0967-3849
1573-6849
DOI:10.1007/s10577-010-9118-y