Influence of cereal bran supplement on cadmium effects in growing rats

• Published in: Human & experimental toxicology 2010-06, Vol.29 (6), p.467-476
• Main Authors: Callegaro, Mgk, Milbradt, BG, Diettrich, T., Alves, E., Duarte, FA, Flores, EMM, Dressler, VL, Silva, LP, Emanuelli, T.
• Format: Article
• Language: English
• Subjects: Alanine transaminase; Animal Feed - analysis; Animals; Biological and medical sciences; Cadmium; Cadmium - administration & dosage; Cadmium - analysis; Cadmium - toxicity; Cereals; Chemical and industrial products toxicology. Toxic occupational diseases; Contamination; Diet; Dietary fiber; Dietary Fiber - administration & dosage; Dietary Fiber - analysis; Dietary supplements; Dietary Supplements - analysis; Diets; Dose-Response Relationship, Drug; Edible Grain; Fibers; Intestinal Absorption; Kidney; Kidney - chemistry; Kidney - drug effects; Kidney - metabolism; Liver Function Tests; Male; Malnutrition; Medical sciences; Metals and various inorganic compounds; Minerals; Minerals - administration & dosage; Minerals - analysis; Porphobilinogen Synthase - metabolism; Protective Agents - administration & dosage; Protective Agents - analysis; Random Allocation; Rats; Rats, Wistar; Rodents; Toxicity; Toxicology; Weight Gain - drug effects
• ISSN: 0960-3271; 1477-0903
• DOI: 10.1177/0960327109357777

Strategies to diminish cadmium (Cd) absorption are highly desirable especially where Cd exposure due to environmental contamination is still inevitable. Cd toxicity may be influenced by dietary components, such as fiber and minerals. Multimixtures are low-cost cereal bran supplements used in Brazil and in other countries to counteract malnutrition in low-income populations. This study was aimed at evaluating whether multimixture would reduce Cd effects in young rats. Animals received a diet with or without the multimixture plus 0, 5, or 25 mg Cd/kg (control, Cd-5, and Cd-25 groups) during 30 days. The Cd-5 groups were similar to control groups in all parameters analyzed, except in the higher renal Cd concentration. However, the Cd-25 groups had lower biological growth parameters and renal δ-aminolevulinate dehydratase activity, besides higher renal Cd concentration and plasma alanine aminotransferase activity compared to the controls. The multimixture did not prevent Cd effects in the Cd-25 group, but caused a small reduction in renal Cd concentration in the Cd-5 group. Although this multimixture was ineffective to prevent Cd effects at the higher concentration, it seemed to reduce Cd accumulation at the lower Cd dietary concentration, which is similar to levels of human exposure in some polluted areas.