Frequency of positive anti thyroid peroxidase antibody titers among normal individuals

Anti-thyroid peroxidase antibodies have a pathogenic role in Hashimoto thyroiditis. Between 10 and 19% of individuals without thyroid disease, have positive titers of these antibodies. To study the frequency of positive titers of anti-thyroid peroxidase antibodies in healthy individuals. A blood sam...

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Bibliographic Details
Published in:Revista medíca de Chile 2010-01, Vol.138 (1), p.15-21
Main Authors: Lanas, Alejandra, Letelier, Carolina, Caamaño, Egardo, Massardo, Teresa, González, Patricio, Araya, A Verónica
Format: Article
Language:Spanish
Subjects:
Adult
Aged
Antibodies - blood
Biomarkers - blood
Chile - epidemiology
Epidemiologic Methods
Female
Hashimoto Disease - diagnosis
Hashimoto Disease - epidemiology
Humans
Iodide Peroxidase - immunology
Male
Middle Aged
Reference Values
Thyrotropin - blood
Young Adult
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Summary:Anti-thyroid peroxidase antibodies have a pathogenic role in Hashimoto thyroiditis. Between 10 and 19% of individuals without thyroid disease, have positive titers of these antibodies. To study the frequency of positive titers of anti-thyroid peroxidase antibodies in healthy individuals. A blood sample, to measure anti-thyroid peroxidase antibodies and thyroid stimulating hormone (TSH) by chemoluminiscense assay, was obtained from 67women and 62 men aged 45 +/- 14years, without a personal or familiar history of thyroid diseases and normal thyroid palpation. The cutoff point of the manufacturer to consider positive a titer of anti-thyroid peroxidase antibodies was set at 35 IU/ml. Twenty-eight women and 28 men had positive antibody titers (43% of the sample). Subjects in the upper tercile of anti-thyroid peroxidase antibody titers had a higher TSH than those in the second tercile, although within normal limits (1.73 +/- 0.74 and 1.37 +/- 0.59 mlU/L, respectively p = 0.02) CONCLUSIONS: Forty three percent of the studied subjects without personal or familial history of thyroid diseases had positive titers of anti-thyroid peroxidase antibodies. Further prospective studies should evaluate whether this observation discloses an increase in thyroid autoimmune disease in a population with increased iodine intake.
ISSN:0034-9887
DOI:10.4067/S0034-98872010000100002