Immune responses to haemorrhagic septicaemia (HS) vaccination in Trypanosoma evansi infected buffalo-calves

• Published in: Tropical animal health and production 2010-04, Vol.42 (4), p.589-595
• Main Authors: Singla, Lachhman D, Juyal, Prayag D, Sharma, Narinder S
• Format: Article
• Language: English
• Subjects: Agglutination Tests - veterinary; Animals; Antibodies, Bacterial - blood; Bacterial Vaccines - administration & dosage; Bacterial Vaccines - immunology; Biological Assay - methods; Biomedical and Life Sciences; Buffaloes - immunology; Buffaloes - parasitology; Hemorrhagic Septicemia - complications; Hemorrhagic Septicemia - immunology; Hemorrhagic Septicemia - microbiology; Hemorrhagic Septicemia - veterinary; India; Life Sciences; Male; Mice; Parasitemia - immunology; Parasitemia - veterinary; Pasteurella multocida - immunology; Random Allocation; Trypanosoma - immunology; Trypanosoma evansi; Trypanosomiasis - complications; Trypanosomiasis - immunology; Trypanosomiasis - parasitology; Trypanosomiasis - veterinary; Vaccination - veterinary; Vaccines; Veterinary Medicine/Veterinary Science; Zoology
• ISSN: 0049-4747; 1573-7438
• DOI: 10.1007/s11250-009-9461-1

To assess the immunosuppressive effect of Trypanosoma evansi infection in buffalo-calves on immune responses to heterologous antigen, the study was planned to examine the responses of haemorrhagic septicaemia vaccination in simultaneously and previously (80 days before vaccination) T. evansi-infected buffalo-calves. Eight buffalo-calves were divided into three groups. Buffalo-calves of group A (n = 3) were previously (80 days before primary vaccination with haemorrhagic septicaemia [HS] vaccine) infected with T. evansi (1 × 10⁷ tryps.calf⁻¹; sc) and that of group B (n = 3) were infected with T. evansi (1 × 10⁷ tryps.calf⁻¹; sc) on the day of primary vaccination with HS vaccine. Two healthy uninfected control calves given only HS vaccine were kept in group C. All the buffalo-calves were given a booster dose of vaccine 21 days post-primary vaccination (PPV). Twenty eight days PPV, animals of group A were given trypanocidal quinapyramine prosalt at 6.66 mg kg⁻¹. Immunosuppressive effect of T. evansi infection was evident from day 7 PPV with HS vaccine. The effect was more pronounced in previously T. evansi-infected buffalo-calves as compared with simultaneously infected buffalo-calves. Group A buffalo-calves appeared to have recovered from the immunosuppressive effect after 28 days post-trypanocidal treatment as observed by humoral and cell-mediated immune responses. Immunosuppressive effect to HS vaccination was observed in T. evansi-infected buffalo-calves, and trypanocidal therapy enabled the calves to mount the responses similar to uninfected controls.