Correlates of serum dioxin to self-reported exposure factors

The aim of the current analysis was to examine the determinates of lipid-adjusted body levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from occupational histories, age, body mass index, and self-reported information from a questionnaire. We collected serum from 346 workers at a New Zealand chem...

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Bibliographic Details
Published in:Environmental research 2010-02, Vol.110 (2), p.131-136
Main Authors: BURNS, C. J, COLLINS, J. J, HUMPHRY, N, BODNER, K. M, AYLWARD, L. L, MCBRIDE, D
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Aged, 80 and over
Area Under Curve
Biological and medical sciences
Body Mass Index
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical Industry
Cohort Studies
Correlation
Diet
Diets
Dioxins
Employment
Epidemiology
Female
Humans
Male
Medical sciences
Middle Aged
Occupation
Occupational
Occupational Exposure - analysis
Pesticides, fertilizers and other agrochemicals toxicology
Polychlorinated Dibenzodioxins - blood
Questionnaire
Serums
Surveys and Questionnaires
Toxicology
Various organic compounds
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Summary:The aim of the current analysis was to examine the determinates of lipid-adjusted body levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from occupational histories, age, body mass index, and self-reported information from a questionnaire. We collected serum from 346 workers at a New Zealand chemical plant that manufactured and formulated the herbicide, 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). Age, body mass index, and employment history were significant determinates of TCDD. The self-reported data on occupation, residence, and general diet were not predictive of serum levels and we observed no evidence of increased TCDD levels from living close to the site. For participants with putative occupational exposure, employment history and personal factors were important to understand the range of TCDD serum levels. For employees without direct occupational exposure, and resulting lower dioxin levels, we recommend further efforts to develop and validate questionnaires to better evaluate environmental sources of dioxins.
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2009.11.003