Antileukemic activity of substituted ureidothiazoles, ureidothiadiazoles, and related compounds

A number of ureidothiazole and ureidothiadiazole derivatives related to ethyl 4-[[(2-thiazolylamino)carbonyl]-amino]benzoate were prepared and evaluated against the leukemia P-388 tumor system in mice. Preliminary structure-activity relationship study revealed that, among other considerations, activ...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1979-01, Vol.22 (1), p.28-32
Main Authors: Zee-Cheng, Robert K. Y, Cheng, C. C
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemical synthesis
Leukemia, Experimental - drug therapy
Mice
Structure-Activity Relationship
Thiadiazoles - chemical synthesis
Thiadiazoles - pharmacology
Thiazoles - chemical synthesis
Thiazoles - pharmacology
Urea - analogs & derivatives
Urea - chemical synthesis
Urea - pharmacology
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Summary:A number of ureidothiazole and ureidothiadiazole derivatives related to ethyl 4-[[(2-thiazolylamino)carbonyl]-amino]benzoate were prepared and evaluated against the leukemia P-388 tumor system in mice. Preliminary structure-activity relationship study revealed that, among other considerations, active compounds of this series contain either an "isothioureido" [N-C(S-)=N-] or an "isothiosemicarbazono" [N-C(S-)=N-N=] structural unit.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00187a007