Hydrolase-catalyzed fast Henry reaction of nitroalkanes and aldehydes in organic media

Nitroalkanes underwent fast additions to a variety of structurally diverse aldehydes under the catalysis of d-aminoacylase in DMSO. The influences of reaction conditions including solvents, temperature, enzyme concentration and molar ratio of substrates were systematically investigated. Seventeen pr...

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Bibliographic Details
Published in:Journal of biotechnology 2010-02, Vol.145 (3), p.240-243
Main Authors: Wang, Jun-Liang, Li, Xia, Xie, Hong-Yan, Liu, Bo-Kai, Lin, Xian-Fu
Format: Article
Language:English
Subjects:
Aldehyde
Aldehydes - metabolism
Alkanes - metabolism
Benzaldehydes - chemistry
Benzaldehydes - metabolism
Biocatalysis
Biological and medical sciences
Biotechnology
Ethane - analogs & derivatives
Ethane - chemistry
Ethane - metabolism
Fundamental and applied biological sciences. Psychology
Henry reaction
Hydrolase
Hydrolases - metabolism
Models, Chemical
Nitro Compounds - metabolism
Nitroalkanes
Nitroparaffins - chemistry
Nitroparaffins - metabolism
Solvents - metabolism
Substrate Specificity
β-Nitroalkanols
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Description
Summary:Nitroalkanes underwent fast additions to a variety of structurally diverse aldehydes under the catalysis of d-aminoacylase in DMSO. The influences of reaction conditions including solvents, temperature, enzyme concentration and molar ratio of substrates were systematically investigated. Seventeen products were obtained in short time with moderate to high yields. It is the first report on hydrolase-catalyzed fast Henry reaction in organic solvent.
ISSN:0168-1656
1873-4863
DOI:10.1016/j.jbiotec.2009.11.022