Gap Junctions and Neuronal Injury: Protectants or Executioners?

The authors review concepts and recent experimental observations that relate gap junctional communication to the pathophysiology of neuronal injury, specifically ischemic or traumatic damage. The role played by this type of direct intercellular communication during the progression of the injuries ca...

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Bibliographic Details
Published in:The Neuroscientist (Baltimore, Md.) Md.), 2003-02, Vol.9 (1), p.5-9
Main Authors: Velazquez, Jose L. Perez, Frantseva, Marina V., Naus, Christian C.
Format: Article
Language:English
Subjects:
Animals
Brain Ischemia - metabolism
Cell Communication
Central Nervous System - injuries
Central Nervous System - metabolism
Connexins - metabolism
Gap Junctions - metabolism
Humans
Neuroprotective Agents - metabolism
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Summary:The authors review concepts and recent experimental observations that relate gap junctional communication to the pathophysiology of neuronal injury, specifically ischemic or traumatic damage. The role played by this type of direct intercellular communication during the progression of the injuries can be conceived to be either detrimental or beneficial, depending on the arguments employed. The data indicate that, far from being a simple matter of judgment, the contribution of gap junctions to cell injury is a complicated phenomenon that depends on the specific insult and network in which it operates.
ISSN:1073-8584
1089-4098
DOI:10.1177/1073858402239586