Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection

• Published in: Journal of antimicrobial chemotherapy 2010-06, Vol.65 (6), p.1119-1125
• Main Authors: Hirsch, Elizabeth B., Tam, Vincent H.
• Format: Article
• Language: English
• Subjects: Aminoglycosides - therapeutic use; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteria; Bacterial Proteins - biosynthesis; beta-Lactam Resistance; beta-Lactamases - biosynthesis; Biological and medical sciences; carbapenems; Clinical medicine; Drug resistance; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination - methods; Enzymes; Genotype & phenotype; Humans; Klebsiella Infections - drug therapy; Klebsiella Infections - microbiology; Klebsiella pneumoniae; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - enzymology; Klebsiella pneumoniae - isolation & purification; Medical sciences; Microbial Sensitivity Tests - methods; Minocycline - analogs & derivatives; Minocycline - therapeutic use; Pharmacology. Drug treatments; plasmids; Polymyxins - therapeutic use; susceptibility; Treatment Outcome; β-lactamases
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dkq108

Bacteria producing Klebsiella pneumoniae carbapenemases (KPCs) are rapidly emerging as a cause of multidrug-resistant infections worldwide. Bacterial isolates harbouring these enzymes are capable of hydrolysing a broad spectrum of β-lactams including the penicillins, cephalosporins, carbapenems and monobactam. Detection of isolates harbouring carbapenemases can be inconsistent using automated systems, often requiring subsequent confirmatory tests. Phenotypic methods utilizing boronic acid disc tests have demonstrated promising results and appear practical for use in clinical microbiology laboratories. Treatment of infection caused by KPC bacteria is particularly worrisome as the carbapenems are often agents of the last resort for resistant Gram-negative infections. The optimal treatment of infections caused by KPC bacteria is not well established and clinical outcome data remain sparse. We reviewed the current literature regarding clinical outcomes following KPC infections, with a specific effort to summarize the clinical data available for specific antimicrobial agents. A total of 15 papers involving 55 unique patient cases were reviewed. While the total number of patients is relatively small, some useful insights could still be gathered to guide clinicians in the management of KPC infections. Tigecycline and the aminoglycosides were associated with positive outcomes in the majority of cases. Clinical success rates were low when the polymyxins were used as monotherapy, but were much higher when they were used in combination. Studies examining combination therapy and well-controlled clinical trials are needed to ascertain the optimal treatment of infections caused by KPC bacteria.