Anti-inflammatory Activity of Salvianolic Acid B in Microglia Contributes to its Neuroprotective Effect

This study examined whether Salvianolic acid B (Sal B), a major active component of Chinese herb Radix Salviae Miltiorrhizae , may exert an anti-inflammatory effect in microglia and may be neuroprotective by regulating microglial activation. Our results showed that Sal B significantly reduced the pr...

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Bibliographic Details
Published in:Neurochemical research 2010-07, Vol.35 (7), p.1029-1037
Main Authors: Wang, Shao-Xia, Hu, Li-Min, Gao, Xiu-Mei, Guo, Hong, Fan, Guan-Wei
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Benzofurans - pharmacology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Survival - drug effects
Coculture Techniques
Interleukin-1beta - biosynthesis
Interleukin-1beta - genetics
Lipopolysaccharides - pharmacology
Microglia - drug effects
Microglia - physiology
Neurochemistry
Neurology
Neurons - drug effects
Neurons - physiology
Neuroprotective Agents - pharmacology
Neurosciences
NF-kappa B - metabolism
Nitric Oxide - biosynthesis
Nitric Oxide - genetics
Original Paper
Rats
Rats, Wistar
Reactive Oxygen Species - metabolism
RNA, Messenger - biosynthesis
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - genetics
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Summary:This study examined whether Salvianolic acid B (Sal B), a major active component of Chinese herb Radix Salviae Miltiorrhizae , may exert an anti-inflammatory effect in microglia and may be neuroprotective by regulating microglial activation. Our results showed that Sal B significantly reduced the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and reactive oxygen species (ROS) induced by lipopolysaccharide (LPS) treatment in rat primary microglia in a dose-dependent manner. Sal B had no effects on ATP-dependent IL-1β release and interferon (IFN)-γ-induced NO production. Sal B also suppressed LPS-induced inducible nitric oxide synthase (iNOS), TNF-α, and IL-1β mRNA expression, which was accompanied by inhibiting transcription factor NF-κB activation. Sal B could protect neurons through inhibition of microglial activation in a microglia-neuron coculture system. In conclusion, these data demonstrate that anti-inflammatory activity of Sal B in microglia contributes to its neuroprotective effect and suggest that it may be useful for preventing microglia-mediated neuroinflammation.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-010-0151-1