Distribution of Two Common Idiotypes of Anticardiolipin Antibodies in Sera of Patients with Primary Antiphospholipid Syndrome, Systemic Lupus Erythematosus and Monoclonal Gammopathies

The frequency of two common idiotypes of anticardiolipin antibodies (aCL) was determined in sera from three groups of subjects, patients with systemic lupus erythematosus (SLE), with primary antiphospholipid syndrome (PAPS) and with monoclonal gammopathies (MG), as compared to normal population. The...

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Bibliographic Details
Published in:Lupus 1992-02, Vol.1 (2), p.91-96
Main Authors: Krause, I., Cohen, J., Blank, M., Bakimer, R., Cartman, A., Hohmann, A., Valesini, G., Asherson, R.A., Khamashta, M.A., Hughes, G.R.V., Shoenfeld, Y.
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Anticardiolipin - blood
Antibodies, Anticardiolipin - classification
Antibodies, Antinuclear - blood
Antiphospholipid Syndrome - immunology
Cross Reactions
Female
Humans
Immunoglobulin G - blood
Immunoglobulin Idiotypes - blood
Immunoglobulin M - blood
Lupus Erythematosus, Systemic - immunology
Male
Middle Aged
Paraproteinemias - immunology
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Summary:The frequency of two common idiotypes of anticardiolipin antibodies (aCL) was determined in sera from three groups of subjects, patients with systemic lupus erythematosus (SLE), with primary antiphospholipid syndrome (PAPS) and with monoclonal gammopathies (MG), as compared to normal population. The idiotype 1.10, which was derived from a patient with active SLE and antiphospholipid syndrome, was found more frequently among patients with PAPS (10.5%, 10.5% and 22.20% in MG, SLE and PAPS, respectively) than the idiotype H3, which was derived from a human hybridoma monoclonal aCL generated from a healthy subject immunized with tetanus and diphtheria. The latter idiotype was detected in 8.7%, 6.5% and 11.7% of patients with MG, SLE and PAPS, respectively. Incidental findings in this study include a high prevalence of aCL among patients with MG (23%) and a high prevalence of anti-dsDNA antibodies, detected only by a sensitive enzyme-linked immunosorbent assay, among patients with PAPS. Our results indicate that idiotypic diversity exists among aCL derived from different sources. Some of these cross-reactive idiotypes may be more pathogenic than others.
ISSN:0961-2033
1477-0962
DOI:10.1177/096120339200100206