Evaluation of the genotoxicity of Fusarium mycotoxin moniliformin in human peripheral blood lymphocytes

Mycotoxins are fungal secondary metabolites that can be found in contaminated food and feed. There is some evidence to suggest that certain mycotoxins may be mutagenic. Here, we investigate the genotoxicity of the mycotoxin moniliformin (MON) (3-hydroxycyclobut-3-ene-1,2-dione) in human peripheral b...

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Bibliographic Details
Published in:Environmental and molecular mutagenesis 2009-06, Vol.50 (5), p.431-434
Main Authors: Çelik, Mustafa, Yılmaz, Serkan, Aksoy, Hüseyin, Ünal, Fatma, Yüzbaşıoğlu, Deniz, Dönbak, Lale
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cells, Cultured
chromosomal aberrations (CA)
Chromosome Aberrations - chemically induced
Cyclobutanes - chemistry
Cyclobutanes - toxicity
Fundamental and applied biological sciences. Psychology
Fusarium
Fusarium - metabolism
Genetics of eukaryotes. Biological and molecular evolution
genotoxicity
Humans
Lymphocytes - drug effects
Lymphocytes - metabolism
Medical sciences
Micronuclei, Chromosome-Defective - chemically induced
micronucleus (MN) assay
Micronucleus Tests
Molecular Structure
moniliformin
Mycotoxins - chemistry
Mycotoxins - toxicity
Sister Chromatid Exchange - drug effects
sister-chromatid exchange (SCE)
Toxicology
Young Adult
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Summary:Mycotoxins are fungal secondary metabolites that can be found in contaminated food and feed. There is some evidence to suggest that certain mycotoxins may be mutagenic. Here, we investigate the genotoxicity of the mycotoxin moniliformin (MON) (3-hydroxycyclobut-3-ene-1,2-dione) in human peripheral blood lymphocytes using chromosomal aberration (CA), sister-chromatid exchange (SCE), and micronucleus (MN) analysis. Lymphocyte cultures were treated for 48 h with six different concentrations of MON between 2.5 and 25 μM. CA, SCE, and MN frequencies were significantly increased in a dose-dependent manner compared with the negative control. The mitotic, replication, and cytokinesis-block proliferation indices were not affected by treatment with MON. The results provide evidence to demonstrate that MON can exert cytogenetic effects in human cells in culture. Environ. Mol. Mutagen. 2009.
ISSN:0893-6692
1098-2280
DOI:10.1002/em.20459