Persistent Circulation of Highly Pathogenic Influenza H5N1 Virus in Lake Qinghai Area of China

To trace the endemic situation of highly pathogenic influenza H5N1 virus in wildlife in the Lake Qinghai area of northwest China, a continuous surveillance program was implemented from September 2005 to September 2007. A total of 2699 field samples were collected, and 95 of the samples were positive...

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Bibliographic Details
Published in:Avian diseases 2010-06, Vol.54 (2), p.821-829
Main Authors: Li, Yongdong, Li, Peng, Lei, Fumin, Guo, Shan, Ding, Changqing, Xin, Zhi, He, Yubang, Yan, Baoping, Kou, Zheng, Tang, Shuang, Zhang, Zhong, Hu, Zhihong, Li, Tianxian
Format: Article
Language:English
Subjects:
Animal Migration
Animals
avian influenza
Birds
China - epidemiology
disease detection
disease surveillance
Female
geographical variation
H5N1 subtype
H5N1 subtype influenza A virus
hemagglutinins
highly pathogenic avian influenza H5N1
Influenza A virus
Influenza A Virus, H5N1 Subtype - genetics
Influenza in Birds - epidemiology
Influenza in Birds - virology
Influenza virus
lakes
Mice
Mice, Inbred BALB C
microbial genetics
Orthomyxoviridae
pathogen identification
pathogenicity
Phylogeny
Qinghai
Regular s
Reverse transcriptase polymerase chain reaction
seasonal variation
sialidase
species differences
Summer
Surveillance
Time Factors
vertebrate viruses
virus transmission
Viruses
water birds
Waterfowl
Wild birds
wildlife
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Summary:To trace the endemic situation of highly pathogenic influenza H5N1 virus in wildlife in the Lake Qinghai area of northwest China, a continuous surveillance program was implemented from September 2005 to September 2007. A total of 2699 field samples were collected, and 95 of the samples were positive by a reverse transcription–polymerase chain reaction (RT-PCR) test of subtype H5 influenza virus. To some extent, the detection rate correlated with the species, the location, and the seasons of collection. In 2007, two H5N1 isolates were identified from two species of migratory birds. The two 2007 isolates showed high similarities of the hemagglutinin and neuraminidase genes with those of the 2005 and 2006 Qinghai isolates (98.6–99.8% for HA and 98.7–98.9% for NA at the nucleotide level). Both isolates fell into clade 2.2.2 and were experimentally highly pathogenic to chickens and mice. According to our surveillance results, HPAI H5N1 viruses still exist in this region.
ISSN:0005-2086
1938-4351
DOI:10.1637/8657-021309-Reg.1