Acute hypoxia promote the phosphorylation of tau via ERK pathway

Tau phosphorylation and hypoxia are both linked to the pathology of Alzheimer's disease. To find out the possible connection between hypoxia and tau phosphorylation, we performed this study to evaluate the level of phosphorylated tau under hypoxic or normal condition. We found in our study that...

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Bibliographic Details
Published in:Neuroscience letters 2010-05, Vol.474 (3), p.173-177
Main Authors: Fang, Hui, Zhang, Li-Feng, Meng, Fan-Tao, Du, Xin, Zhou, Jiang-Ning
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Cell Hypoxia - physiology
Cell Line
Cell Proliferation
ERK
Extracellular Signal-Regulated MAP Kinases - metabolism
Hippocampus - metabolism
Hippocampus - physiopathology
Humans
Hypoxia
Hypoxia - physiopathology
Immunoblotting
Mice
Mice, Inbred C57BL
Phosphorylation
Signal Transduction - physiology
Tau
tau Proteins - metabolism
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Summary:Tau phosphorylation and hypoxia are both linked to the pathology of Alzheimer's disease. To find out the possible connection between hypoxia and tau phosphorylation, we performed this study to evaluate the level of phosphorylated tau under hypoxic or normal condition. We found in our study that hypoxia promoted the phosphorylation of tau protein via ERK pathway, which suggest hypoxia might be involved in the process of tau pathology.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2010.03.037