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Acute hypoxia promote the phosphorylation of tau via ERK pathway
Tau phosphorylation and hypoxia are both linked to the pathology of Alzheimer's disease. To find out the possible connection between hypoxia and tau phosphorylation, we performed this study to evaluate the level of phosphorylated tau under hypoxic or normal condition. We found in our study that...
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| Published in: | Neuroscience letters 2010-05, Vol.474 (3), p.173-177 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c444t-93adf8ff84216de336e82b9f9cf083582390db79ee24486614f98e50cc27e70b3 |
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| cites | cdi_FETCH-LOGICAL-c444t-93adf8ff84216de336e82b9f9cf083582390db79ee24486614f98e50cc27e70b3 |
| container_end_page | 177 |
| container_issue | 3 |
| container_start_page | 173 |
| container_title | Neuroscience letters |
| container_volume | 474 |
| creator | Fang, Hui Zhang, Li-Feng Meng, Fan-Tao Du, Xin Zhou, Jiang-Ning |
| description | Tau phosphorylation and hypoxia are both linked to the pathology of Alzheimer's disease. To find out the possible connection between hypoxia and tau phosphorylation, we performed this study to evaluate the level of phosphorylated tau under hypoxic or normal condition. We found in our study that hypoxia promoted the phosphorylation of tau protein via ERK pathway, which suggest hypoxia might be involved in the process of tau pathology. |
| doi_str_mv | 10.1016/j.neulet.2010.03.037 |
| format | article |
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To find out the possible connection between hypoxia and tau phosphorylation, we performed this study to evaluate the level of phosphorylated tau under hypoxic or normal condition. We found in our study that hypoxia promoted the phosphorylation of tau protein via ERK pathway, which suggest hypoxia might be involved in the process of tau pathology.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2010.03.037</identifier><identifier>PMID: 20304032</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Alzheimer's disease ; Animals ; Cell Hypoxia - physiology ; Cell Line ; Cell Proliferation ; ERK ; Extracellular Signal-Regulated MAP Kinases - metabolism ; Hippocampus - metabolism ; Hippocampus - physiopathology ; Humans ; Hypoxia ; Hypoxia - physiopathology ; Immunoblotting ; Mice ; Mice, Inbred C57BL ; Phosphorylation ; Signal Transduction - physiology ; Tau ; tau Proteins - metabolism</subject><ispartof>Neuroscience letters, 2010-05, Vol.474 (3), p.173-177</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>2010 Elsevier Ireland Ltd. 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| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2010-05, Vol.474 (3), p.173-177 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
| subjects | Alzheimer's disease Animals Cell Hypoxia - physiology Cell Line Cell Proliferation ERK Extracellular Signal-Regulated MAP Kinases - metabolism Hippocampus - metabolism Hippocampus - physiopathology Humans Hypoxia Hypoxia - physiopathology Immunoblotting Mice Mice, Inbred C57BL Phosphorylation Signal Transduction - physiology Tau tau Proteins - metabolism |
| title | Acute hypoxia promote the phosphorylation of tau via ERK pathway |
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