Pneumocystis carinii Pneumonia in Patients with Systemic Lupus Erythematosus

At the University Hospital, Kuala Lumpur, Malaysia, nine patients with systemic lupus erythematosus (SLE) were treated for Pneumocystis carinii pneumonia (PCP) between January 1987 and December 1988. When they developed PCP all the patients' SLE disease course was active and eight of them were...

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Bibliographic Details
Published in:Lupus 1992-12, Vol.1 (6), p.379-385
Main Authors: Liam, Chong-Kin, Wang, Florence
Format: Article
Language:English
Subjects:
Adolescent
Adult
Female
Humans
Immunosuppressive Agents - adverse effects
Lupus Erythematosus, Systemic - complications
Male
Opportunistic Infections - etiology
Pneumocystis carinii
Pneumonia, Pneumocystis - drug therapy
Pneumonia, Pneumocystis - etiology
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Summary:At the University Hospital, Kuala Lumpur, Malaysia, nine patients with systemic lupus erythematosus (SLE) were treated for Pneumocystis carinii pneumonia (PCP) between January 1987 and December 1988. When they developed PCP all the patients' SLE disease course was active and eight of them were on prednisolone. Four of these eight patients were also receiving cyclophosphamide. Patients who were on more intensive immunosuppressive therapy were found to develop more severe PCP. All the patients except one were treated with high-dose cotrimoxazole. Four patients responded to antipneumocystis treatment and survived, while PCP was responsible for the death of the five non-survivors.
ISSN:0961-2033
1477-0962
DOI:10.1177/096120339200100607