The Effect of Narcotics on the Endogenous Respiration and Succinate Oxidation in Oyster Muscle

The action of the following compounds on homogenates of the adductor muscles of Saxostrea commercialis was studied: urethane, phenyl urethane, chloral hydrate, salicylic acid, morphine, caffeine, barbitone, benzoic acid, salicylamide and benzamide. It was found that, except for 0·05 M urethane, the...

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Bibliographic Details
Published in:Journal of the Marine Biological Association of the United Kingdom 1948-04, Vol.27 (2), p.504-512
Main Author: Humphrey, George Frederick
Format: Article
Language:English
Subjects:
Cell Respiration
Muscles
Narcotics
Old Medline
Ostreidae
Oxidation-Reduction
Succinates
Succinic Acid
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Summary:The action of the following compounds on homogenates of the adductor muscles of Saxostrea commercialis was studied: urethane, phenyl urethane, chloral hydrate, salicylic acid, morphine, caffeine, barbitone, benzoic acid, salicylamide and benzamide. It was found that, except for 0·05 M urethane, the endogenous oxygen consumption was reduced by all these compounds when present in concentrations ranging from o·001 to 0·05M. The oxidation of succinic acid was partially inhibited by these substances. These findings are discussed in relation to similar studies on other tissues.
ISSN:0025-3154
1469-7769
DOI:10.1017/S0025315400025492