IgM Receptors on Human Lymphocytes: Detection by Direct Binding

Radioiodinated IgM isolated from a patient with Waldenstrom macroglobulinemia binds with high avidity (apparent Ka= 2.5 × 109M-1) to freshly isolated human peripheral blood lymphocytes. Binding occurred through the Fc region of the molecule and involved a receptor specific for immunoglobulins of the...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1979-02, Vol.76 (2), p.912-914
Main Authors: Hardin, John A., Nakaoka, Kurt K., Carboni, Joan M.
Format: Article
Language:English
Subjects:
Antigen-Antibody Complex
B lymphocytes
Binding Sites
Binding, Competitive
Electrophoresis
Gels
Humans
Immunoglobulin Fc Fragments
Immunoglobulin G - metabolism
Immunoglobulin M - metabolism
Immunology
Kinetics
Lymphocytes
Lymphocytes - immunology
Lymphocytes - metabolism
Molecules
Radioactive decay
Receptors
T lymphocytes
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Description
Summary:Radioiodinated IgM isolated from a patient with Waldenstrom macroglobulinemia binds with high avidity (apparent Ka= 2.5 × 109M-1) to freshly isolated human peripheral blood lymphocytes. Binding occurred through the Fc region of the molecule and involved a receptor specific for immunoglobulins of the IgM class. The avidity and specificity of this binding are consistent with a biologic role for IgM receptors on lymphocytes.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.76.2.912