Identification of hydroxyapatite crystals in synovial fluid

A semiquantitative technique employing (14C) ethane‐1‐hydroxy 1, ‐1‐diphosphonate (EHDP) binding has been used to detect crystals, presumably hydroxyapatite, in human synovial fluid samples which were handled to prevent the formation of artifactual mineral phase. Binding material was found in 29% of...

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Bibliographic Details
Published in:Arthritis and rheumatism 1979-04, Vol.22 (4), p.389-395
Main Authors: Halverson, Paul B., Mccarty, Daniel J.
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Juvenile - metabolism
Arthritis, Rheumatoid - metabolism
Chondrocalcinosis - metabolism
Etidronic Acid
Female
Humans
Hydroxyapatites - analysis
Joint Diseases - metabolism
Male
Methods
Middle Aged
Osteoarthritis - metabolism
Osteoarthropathy, Primary Hypertrophic - metabolism
Spondylitis - metabolism
Synovial Fluid - analysis
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Summary:A semiquantitative technique employing (14C) ethane‐1‐hydroxy 1, ‐1‐diphosphonate (EHDP) binding has been used to detect crystals, presumably hydroxyapatite, in human synovial fluid samples which were handled to prevent the formation of artifactual mineral phase. Binding material was found in 29% of noninflammatory and in none of inflammatory joint fluids. Nuclide binding material was strongly correlated with the presence of CPPD crystals and with radiographic evidence of cartilaginous degeneration.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780220412