Amino Acid Effect on Aspirin Stability in Propylene Glycol

Temperature stability studies were conducted on 0.36M (6.5% w/v) aspirin solutions including either 0.02ML-methionine or 0.02M histidine in propylene glycol. Aspirin was determined spectrophoto-fluorometrically as salicylic acid content at 412nm. A 0.36M aspirin in polyethylene glycol 400 solution w...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1979-05, Vol.68 (5), p.645-648
Main Authors: Narang, Prem K., Lim, James K.
Format: Article
Language:English
Subjects:
Amino Acids
Aspirin - analysis
Aspirin-stability in propylene glycol
Aspirin—stability in propylene glycol effect of L-methionine and histidine, temperature
Drug Stability
effect of L-methionine and histidine
Propylene glycol-stability of aspirin solutions
Propylene Glycols
Propylene glycol—stability of aspirin solutions effect of L-methionine and histidine, temperature
Solvents
Spectrometry, Fluorescence
Stability-aspirin in propylene glycol
Stability—aspirin in propylene glycol effect of L-methionine and histidine, temperature
Temperature
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Summary:Temperature stability studies were conducted on 0.36M (6.5% w/v) aspirin solutions including either 0.02ML-methionine or 0.02M histidine in propylene glycol. Aspirin was determined spectrophoto-fluorometrically as salicylic acid content at 412nm. A 0.36M aspirin in polyethylene glycol 400 solution was studied concurrently. Aspirin degradation rate constants, k, obtained from semilogarithmic plots of percent drug remaining versus time at 30–70±0.5° were used for preparing Arrhenius plots. Good correlation was seen between predicted aspirin stability and experimental k25°- values. L-Methionine and histidine markedly reduced aspirin stability.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600680536