Cloned fragments of the plasmid ColV,I-K94 specifying virulence and serum resistance

A cloned Bam H1-generated fragment of ColV,I-K94 increased the virulence of Escherichia coli , causing an approximately 100-fold reduction in LD 50 for chicks. A genetic determinant f or resistance to the bactericidal effects of serum was mapped to a 5,300 base-pair sequence within the fragment. Nei...

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Bibliographic Details
Published in:Nature (London) 1979-06, Vol.279 (5716), p.778-781
Main Authors: Hardy, K. G, Davies, D. L, Binns, M. M
Format: Article
Language:English
Subjects:
Animals
Blood Bactericidal Activity
Chickens
Chromosome Mapping
Colicins - biosynthesis
Colicins - genetics
Conjugation, Genetic
Escherichia coli - genetics
Escherichia coli - pathogenicity
Escherichia coli Infections
Genetic Linkage
Humanities and Social Sciences
multidisciplinary
Plasmids
Science
Science (multidisciplinary)
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Summary:A cloned Bam H1-generated fragment of ColV,I-K94 increased the virulence of Escherichia coli , causing an approximately 100-fold reduction in LD 50 for chicks. A genetic determinant f or resistance to the bactericidal effects of serum was mapped to a 5,300 base-pair sequence within the fragment. Neither colicin V nor immunity to colicin V affected the pathogenicity of E. coli for chicks.
ISSN:0028-0836
1476-4687
DOI:10.1038/279778a0