Histofluorescence techniques provide evidence for dopamine-containing neuronal elements in canine kidney

Changes induced by hydrochloric acid in the excitation spectrum of catecholamine fluorophores associated with the innervation of the canine renal vasculature show that there are neuronal elements at the glomerular vascular poles containing predominantly dopamine. In contrast, the catecholamine fluor...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1979-08, Vol.205 (4405), p.497-499
Main Authors: Dinerstein, R.J, Vannice, J, Henderson, R.C, Roth, L.J, Goldberg, L.I, Hoffmann, P.C
Format: Article
Language:English
Subjects:
Anatomy
Animals
Arteries
Canines
Cardiovascular system
Catecholamines
Catecholamines - analysis
Dogs
Dopamine
Dopamine - analysis
Emission spectra
Excretion
Fluorescence
Hydrochloric acid
Kidney
Kidney Glomerulus - analysis
Kidney Glomerulus - blood supply
Kidney Glomerulus - innervation
Kidneys
Microscopy, Fluorescence
Neurons - analysis
Norepinephrine
Norepinephrine - analysis
Physiological aspects
Renal circulation
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Summary:Changes induced by hydrochloric acid in the excitation spectrum of catecholamine fluorophores associated with the innervation of the canine renal vasculature show that there are neuronal elements at the glomerular vascular poles containing predominantly dopamine. In contrast, the catecholamine fluorescence in the periadventitial layer of the arcuate arteries is derived from norepinephrine. The dopamine-containing structures may represent the prejunctional counterpart to the pharmacologically identified dopamine receptors in the renal vasculature. As such, this system may be involved in the normal regulation of renal blood flow and renin release.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.451614