The force-interval relationship of the left ventricle

We have carried out a quantitative analysis of the force-interval relationship of the human left ventricle and compared it to previous studies done in both intact subjects as well as isolated muscle. The characteristics of the force-interval relationship of the normal patient resembed those of norma...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1979-08, Vol.60 (2), p.334-348
Main Authors: Anderson, P A, Manring, A, Serwer, G A, Benson, D W, Edwards, S B, Armstrong, B E, Sterba, R J, Floyd, R D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood Pressure
Cardiac Complexes, Premature - physiopathology
Child
Child, Preschool
Echocardiography
Electrocardiography
Heart - physiology
Heart Diseases - physiopathology
Heart Rate
Heart Ventricles - anatomy & histology
Humans
Infant
Myocardial Contraction
Papillary Muscles - anatomy & histology
Papillary Muscles - physiology
Stroke Volume
Systole
Time Factors
Ventricular Function
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Summary:We have carried out a quantitative analysis of the force-interval relationship of the human left ventricle and compared it to previous studies done in both intact subjects as well as isolated muscle. The characteristics of the force-interval relationship of the normal patient resembed those of normal isolated mammalian muscle (except when exposed to high levels of catecholamines). The relationship in group 2 (patients with increased left ventricular dimensions and normal pressure indices) resembled those obtained from isolated muscles from hypertrophied hearts. The relationship from group 3 (patients with increased left ventricular EDDs and depressed pressure indices, two of whom were in clinical heart failure) resumbled those induced in normal muscles exposed to high levels of catecholamines, and those obtained from experimentally induced heart failure. The force-interval relationships of the four patients who fell into the third group were strikingly different from the other groups. This suggests that the force-interval relationship may be useful to describe changes in the inotropic state of the patient's heart.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.60.2.334