Preparation of Nanoaggregates through Self-assembly of Amphiphilic Polyrotaxane Composed of PLLA–PEG–PLLA Triblock Copolymer and α-Cyclodextrins

An amphiphilic polyrotaxane (PRX) composed of biodegradable triblock copolymer of poly(ethylene glycol) (PEG) and poly(L-lactide) (PLLA), PLLA–PEG–PLLA, and many α-cyclodextrins (α-CD) threaded on the triblock copolymer was successfully synthesized. The PRX was found to be self-assembled into vesicl...

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Bibliographic Details
Published in:Chemistry letters 2010-03, Vol.39 (3), p.250-251
Main Authors: Nagahama, Koji, Ohmura, Junpei, Sakaue, Hiromi, Ouchi, Tatsuro, Ohya, Yuichi, Yui, Nobuhiko
Format: Article
Language:English
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Summary:An amphiphilic polyrotaxane (PRX) composed of biodegradable triblock copolymer of poly(ethylene glycol) (PEG) and poly(L-lactide) (PLLA), PLLA–PEG–PLLA, and many α-cyclodextrins (α-CD) threaded on the triblock copolymer was successfully synthesized. The PRX was found to be self-assembled into vesicle-like water-soluble nanoaggregates in an aqueous solution.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2010.250