RNA interference: potential therapeutic targets

One of the most exciting findings in recent years has been the discovery of RNA interference (RNAi). RNAi methodologies hold the promise to selectively inhibit gene expression in mammals. RNAi is an innate cellular process activated when a double-stranded RNA (dsRNA) molecule of greater than 19 dupl...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2004-11, Vol.65 (6), p.649-657
Main Authors: JANA, S, CHAKRABORTY, C, NANDI, S, DEB, J. K
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotechnology
Cancer
Double-stranded RNA
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Silencing
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Infection
Miscellaneous
Neoplasms - drug therapy
Nervous System Diseases - drug therapy
Q1
Reviews
Ribonucleic acid
RNA
RNA Interference
RNA, Small Interfering - therapeutic use
RNA-mediated interference
Virus Diseases - drug therapy
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Summary:One of the most exciting findings in recent years has been the discovery of RNA interference (RNAi). RNAi methodologies hold the promise to selectively inhibit gene expression in mammals. RNAi is an innate cellular process activated when a double-stranded RNA (dsRNA) molecule of greater than 19 duplex nucleotides enters the cell, causing the degradation of not only the invading dsRNA molecule, but also single-stranded (ssRNAs) RNAs of identical sequences, including endogenous mRNAs. The use of RNAi for genetic-based therapies has been widely studied, especially in viral infections, cancers, and inherited genetic disorders. As such, RNAi technology is a potentially useful method to develop highly specific dsRNA-based gene-silencing therapeutics.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-004-1732-1