A Cross-Sectional Study for the Analysis of Clinical, Sexual and Laboratory Conditions Associated to Peyronie's Disease

• Published in: Journal of sexual medicine 2010-04, Vol.7 (4pt1), p.1529-1537
• Main Authors: Rhoden, Ernani Luis, Riedner, Charles Edison, Fuchs, Sandra, Ribeiro, Eduardo Porto, Halmenschlager, Graziele
• Format: Article
• Language: English
• Subjects: Aged; Associated Factor; Blood Glucose - metabolism; Body Mass Index; Brazil; Case-Control Studies; Comorbidities in Peyronies Disease; Comorbidity; Cross-Sectional Studies; Dehydroepiandrosterone Sulfate - blood; Dupuytren Contracture - diagnosis; Dupuytren Contracture - epidemiology; Dyslipidemia; Erectile Dysfunction; Erectile Dysfunction - diagnosis; Erectile Dysfunction - epidemiology; Erectile Dysfunction - ethnology; European Continental Ancestry Group; Humans; Lipids - blood; Male; Middle Aged; Obesity; Penile Induration - diagnosis; Penile Induration - epidemiology; Penile Induration - ethnology; Peyronie's Disease; Risk Factors; Sexual Behavior; Socioeconomic Factors; Sodium Chloride Symporter Inhibitors - adverse effects; Testosterone - blood; Waist Circumference
• ISSN: 1743-6095; 1743-6109
• DOI: 10.1111/j.1743-6109.2009.01584.x

Although Peyronie's Disease (PD) was first described over 250 years ago, its precise etiology remains obscure. Analyze a variety of potential associated factors with PD, including erectile dysfunction. This cross-sectional study included 83 consecutive men with PD and 252 age-matched controls. All men completed the International Index of Erectile Function (IIEF) and were evaluated regarding their clinical and demographic characteristics, comorbidities, and used medications. Anthropometric measures included body mass index and waist circumference (WC). Fasting blood glucose, lipid profile, total testosterone, and dehydroepiandrosterone-sulfate were determined. Clinical and laboratory characteristics associated to PD. The mean age was 59.2±10 years in the cases and 59.7±12 years in the controls. Marital status, current smoking, and excessive consumption of alcoholic beverages were similar between groups (P>0.05). PD was more common among white skin color males (P=0.001). The mean score for each IIEF domain and the androgen levels were similar in the two groups. Thiazides were the only medication associated to PD (P=0.03). Dupuytren's disease was more frequent among individuals with PD (P=0.001). The distribution of all other comorbidities investigated was similar between groups (P>0.05). The characteristics WC>102cm and levels of low-density lipoprotein (LDL)>130mg/dL were more prevalent in the controls (P130mg/dL (OR: 0.55, 95%CI: 0.32–0.92) and WC>102cm (OR: 0.53, 95%CI: 0.29–0.96) were inversely associated to PD. In this study, PD was more common among white skin colored males. An inverse relationship with the presence of elevated serum levels of LDL and WC was observed. We found no association with medications other than thiazides and comorbidities other than Dupuytren's disease. Androgen serum levels and sexual dysfunction had also no association to PD. Rhoden EL, Riedner CE, Fuchs S, Ribeiro EP, and Halmenschlager G. A cross-sectional study for the analysis of clinical, sexual and laboratory conditions associated to Peyronie's disease.