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Micelles based on HPMA copolymers
Polymeric micelles have been under extensive investigation during the past years as drug delivery systems, particularly for anticancer drugs. They are formed by the self-assembly of amphiphilic block copolymers in aqueous solutions and have a spherical shape and a size in the nano-range (< 200 nm...
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Published in: | Advanced drug delivery reviews 2010-02, Vol.62 (2), p.231-239 |
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creator | Talelli, M. Rijcken, C.J.F. van Nostrum, C.F. Storm, G. Hennink, W.E. |
description | Polymeric micelles have been under extensive investigation during the past years as drug delivery systems, particularly for anticancer drugs. They are formed by the self-assembly of amphiphilic block copolymers in aqueous solutions and have a spherical shape and a size in the nano-range (<
200
nm). Tumor accumulation of polymeric micelles upon intravenous administration can occur as a result of the leaky vasculature of tumor tissue (called the enhanced permeation and retention (EPR) effect).To benefit from the EPR effect, polymeric micelles need to have prolonged circulation times as well as high and stable drug loadings. Poly[N-(2-hydroxypropyl) methacrylamide] (pHPMA) is a hydrophilic polymer currently under investigation for its use in polymer–drug conjugates. Its biocompatibility, non-immunogenicity and the possibility for functionalization are properties that resulted in broad pharmaceutical and biomedical applications, also in the micelle technology research. Being hydrophilic, it can serve as a micellar stealth corona, while it can also be modified with hydrophobic moieties to serve as a micellar core in which hydrophobic drugs can be solubilized and retained. HPMA-based polymeric micelles have been showing very promising
in vitro and
in vivo results. This review summarizes the applications of pHPMA in the field of polymeric micelles, either serving as a micellar stealth corona, or, if hydrophobically rendered by derivatization, as a micellar core. |
doi_str_mv | 10.1016/j.addr.2009.11.029 |
format | article |
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200
nm). Tumor accumulation of polymeric micelles upon intravenous administration can occur as a result of the leaky vasculature of tumor tissue (called the enhanced permeation and retention (EPR) effect).To benefit from the EPR effect, polymeric micelles need to have prolonged circulation times as well as high and stable drug loadings. Poly[N-(2-hydroxypropyl) methacrylamide] (pHPMA) is a hydrophilic polymer currently under investigation for its use in polymer–drug conjugates. Its biocompatibility, non-immunogenicity and the possibility for functionalization are properties that resulted in broad pharmaceutical and biomedical applications, also in the micelle technology research. Being hydrophilic, it can serve as a micellar stealth corona, while it can also be modified with hydrophobic moieties to serve as a micellar core in which hydrophobic drugs can be solubilized and retained. HPMA-based polymeric micelles have been showing very promising
in vitro and
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200
nm). Tumor accumulation of polymeric micelles upon intravenous administration can occur as a result of the leaky vasculature of tumor tissue (called the enhanced permeation and retention (EPR) effect).To benefit from the EPR effect, polymeric micelles need to have prolonged circulation times as well as high and stable drug loadings. Poly[N-(2-hydroxypropyl) methacrylamide] (pHPMA) is a hydrophilic polymer currently under investigation for its use in polymer–drug conjugates. Its biocompatibility, non-immunogenicity and the possibility for functionalization are properties that resulted in broad pharmaceutical and biomedical applications, also in the micelle technology research. Being hydrophilic, it can serve as a micellar stealth corona, while it can also be modified with hydrophobic moieties to serve as a micellar core in which hydrophobic drugs can be solubilized and retained. HPMA-based polymeric micelles have been showing very promising
in vitro and
in vivo results. This review summarizes the applications of pHPMA in the field of polymeric micelles, either serving as a micellar stealth corona, or, if hydrophobically rendered by derivatization, as a micellar core.</description><subject>Acrylamides - chemistry</subject><subject>Animals</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug Delivery Systems - trends</subject><subject>Drug targeting</subject><subject>EPR effect</subject><subject>HEMAm</subject><subject>HPMA</subject><subject>Humans</subject><subject>Micelle core</subject><subject>Micelle corona</subject><subject>Micelles</subject><subject>N-(2-hydroxylpropyl) methacrylamide</subject><subject>Nanomedicine - methods</subject><subject>Nanomedicine - trends</subject><subject>Polymeric micelles</subject><subject>Polymers - chemistry</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkMFLwzAchYMobk7_AQ9ST55a80vSpAEvMtQJG3pQ8BbSJIWOdpnJJuy_N2XTo57e5XuPx4fQJeACMPDbZaGtDQXBWBYABSbyCI2hEiSviGTHaJwgmTMsP0boLMYlxkAEx6dolCqYcUnH6HrRGtd1Lma1js5mfpXNXhf3mfFr3-16F-I5Oml0F93FISfo_fHhbTrL5y9Pz9P7eW5oJTY5VJY2pK45k0B5YxgIbTlwATU1GozBWEuBK8JMIwTnzFLGynSO1ZRoV9IJutnvroP_3Lq4UX0bh2965fw2KsFKTpks8f8kZUQCAE8k2ZMm-BiDa9Q6tL0OOwVYDQ7VUg0O1eBQAajkMJWuDvPbunf2t_IjLQF3e8AlHV-tCyqa1q2Ms21wZqOsb__a_wbnIH8D</recordid><startdate>20100217</startdate><enddate>20100217</enddate><creator>Talelli, M.</creator><creator>Rijcken, C.J.F.</creator><creator>van Nostrum, C.F.</creator><creator>Storm, G.</creator><creator>Hennink, W.E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100217</creationdate><title>Micelles based on HPMA copolymers</title><author>Talelli, M. ; Rijcken, C.J.F. ; van Nostrum, C.F. ; Storm, G. ; Hennink, W.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-18d3f2bb649136fc417ad61671b3ca1cc00a970824cf77664d34454094b32ae53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acrylamides - chemistry</topic><topic>Animals</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems - methods</topic><topic>Drug Delivery Systems - trends</topic><topic>Drug targeting</topic><topic>EPR effect</topic><topic>HEMAm</topic><topic>HPMA</topic><topic>Humans</topic><topic>Micelle core</topic><topic>Micelle corona</topic><topic>Micelles</topic><topic>N-(2-hydroxylpropyl) methacrylamide</topic><topic>Nanomedicine - methods</topic><topic>Nanomedicine - trends</topic><topic>Polymeric micelles</topic><topic>Polymers - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Talelli, M.</creatorcontrib><creatorcontrib>Rijcken, C.J.F.</creatorcontrib><creatorcontrib>van Nostrum, C.F.</creatorcontrib><creatorcontrib>Storm, G.</creatorcontrib><creatorcontrib>Hennink, W.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Talelli, M.</au><au>Rijcken, C.J.F.</au><au>van Nostrum, C.F.</au><au>Storm, G.</au><au>Hennink, W.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micelles based on HPMA copolymers</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2010-02-17</date><risdate>2010</risdate><volume>62</volume><issue>2</issue><spage>231</spage><epage>239</epage><pages>231-239</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>Polymeric micelles have been under extensive investigation during the past years as drug delivery systems, particularly for anticancer drugs. They are formed by the self-assembly of amphiphilic block copolymers in aqueous solutions and have a spherical shape and a size in the nano-range (<
200
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in vitro and
in vivo results. This review summarizes the applications of pHPMA in the field of polymeric micelles, either serving as a micellar stealth corona, or, if hydrophobically rendered by derivatization, as a micellar core.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>20004693</pmid><doi>10.1016/j.addr.2009.11.029</doi><tpages>9</tpages></addata></record> |
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source | ScienceDirect Journals |
subjects | Acrylamides - chemistry Animals Drug delivery Drug Delivery Systems - methods Drug Delivery Systems - trends Drug targeting EPR effect HEMAm HPMA Humans Micelle core Micelle corona Micelles N-(2-hydroxylpropyl) methacrylamide Nanomedicine - methods Nanomedicine - trends Polymeric micelles Polymers - chemistry |
title | Micelles based on HPMA copolymers |
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