Structural and chemical aspects of HPMA copolymers as drug carriers

Synthetic strategies and chemical and structural aspects of the synthesis of HPMA copolymer conjugates with various drugs and other biologically active molecules are described and discussed in this chapter. The discussion is held from the viewpoint of design and structure of the polymer backbone and...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2010-02, Vol.62 (2), p.150-166
Main Authors: Ulbrich, Karel, Šubr, Vladimír
Format: Article
Language:English
Subjects:
Acrylamides - administration & dosage
Acrylamides - chemistry
Animals
Anticancer drugs
Biodegradability
Carriers
Conjugates
Copolymers
Drug Carriers - administration & dosage
Drug Carriers - chemistry
Drug delivery systems
Drug Delivery Systems - methods
Drug targeting
Drugs
Genes
Humans
Mathematical analysis
Molecular Structure
N-(2-hydroxypropyl)methacrylamide
Polymer drug conjugates
Polymers - administration & dosage
Polymers - chemistry
Strategy
Synthesis of HPMA copolymers
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Summary:Synthetic strategies and chemical and structural aspects of the synthesis of HPMA copolymer conjugates with various drugs and other biologically active molecules are described and discussed in this chapter. The discussion is held from the viewpoint of design and structure of the polymer backbone and biodegradable spacer between a polymer and drug, structure and methods of attachment of the employed drugs to the carrier and structure and methods of conjugation with targeting moieties. Physicochemical properties of the water-soluble polymer–drug conjugates and polymer micelles including mechanisms of drug release are also discussed. Detailed description of biological behavior of the polymer–drug conjugates as well as application of the copolymers for surface modification and targeting of gene delivery vectors are not included, they are presented and discussed in separate chapters of this issue.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2009.10.007