Surveillance and trends of antimicrobial resistance among clinical isolates of anaerobes in Kuwait hospitals from 2002 to 2007

• Published in: Anaerobe 2010-02, Vol.16 (1), p.1-5
• Main Authors: Jamal, W., Shahin, M., Rotimi, V.O.
• Format: Article
• Language: English
• Subjects: Anaerobes; Anaerobic bacteria; Anti-Bacterial Agents - pharmacology; Bacteria, Anaerobic - drug effects; Bacteria, Anaerobic - isolation & purification; Bacterial Infections - microbiology; Bacteroides fragilis; Drug Resistance, Bacterial; Hospitals; Humans; Kuwait; Microbial Sensitivity Tests; Surveillance; Susceptibility; Trends
• ISSN: 1075-9964; 1095-8274
• DOI: 10.1016/j.anaerobe.2009.04.004

The susceptibility trends for all anaerobes processed by the Anaerobe Reference Laboratory against various antibiotics were determined by using data for 2557 isolates referred by all government hospitals in Kuwait from 2002 to 2007. MIC were determined for the following anti-anaerobic antibiotics: amoxicillin–clavulanic acid, clindamycin, imipenem, meropenem, metronidazole, penicillin, piperacillin, piperacillin–tazobactam and vancomycin (for Gram-positive anaerobes only), using E-test method. The commonest isolates were Bacteroides fragilis (36.8%), followed by Peptostreptococcus spp. (21.9%), Bacteroides ovatus (15.5%) and Prevotella bivia (12.1%). In addition, Prevotella oralis and other Bacteroides spp. represented 8.5% and 8.1% of total number of isolates, respectively. Resistance rate varied among the antimicrobial agents and the species tested. The β-lactams, with the exception of penicillin, were the most active drugs. Piperacillin–tazobactam was the only antimicrobial agent to which all the isolates were uniformly susceptible. Imipenem and metronidazole were highly active with resistance rate of only