Common variable immunodeficiency syndrome associated with epidermodysplasia verruciformis

We report the association of common variable immunodeficiency syndrome with epidermodysplasia verruciformis (EV) manifesting as flat warts and squamous cell carcinomas in a 21-year-old Hispanic woman. Human papillomavirus (HPV) typing by polymerase chain reaction using an EV-HPV primer system, cloni...

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Bibliographic Details
Published in:American journal of clinical dermatology 2007-01, Vol.8 (5), p.307-310
Main Authors: VU, Jenny, WALLACE, Genevieve R, SINGH, Rajendra, DIWAN, Hafeez, PRIETO, Victor, RADY, Peter, TYRING, Stephen, DUVIC, Madeleine
Format: Article
Language:English
Subjects:
Adult
Betapapillomavirus - genetics
Betapapillomavirus - isolation & purification
Biological and medical sciences
Common Variable Immunodeficiency - complications
Common Variable Immunodeficiency - pathology
Common Variable Immunodeficiency - virology
Dermatology
DNA, Viral - analysis
Epidermodysplasia Verruciformis - complications
Epidermodysplasia Verruciformis - pathology
Epidermodysplasia Verruciformis - virology
Female
Human papillomavirus
Humans
Medical sciences
Mouth Mucosa - pathology
Polymerase Chain Reaction
Skin - pathology
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:We report the association of common variable immunodeficiency syndrome with epidermodysplasia verruciformis (EV) manifesting as flat warts and squamous cell carcinomas in a 21-year-old Hispanic woman. Human papillomavirus (HPV) typing by polymerase chain reaction using an EV-HPV primer system, cloning, and sequencing detected HPV-8 and HPV-23 DNAs in the biopsy sample. Our case is the second reported case of common variable immunodeficiency syndrome associated with EV.
ISSN:1175-0561
1179-1888
DOI:10.2165/00128071-200708050-00006