Antibody and cellular immune responses to Plasmodium falciparum histidine-rich protein II in malaria-exposed individuals in Orissa, India

The precise function of Plasmodium falciparum histidine-rich protein II (HRPII) is not known, but in vitro studies have indicated its immunomodulatory function. The host immune response to HRPII was measured and compared with the response to P. falciparum merozoite surface protein 1 (MSP1) in four g...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2010-05, Vol.104 (5), p.371-373
Main Authors: Das, Padmalaya, Grewal, Jasvir S., Chauhan, Virander S.
Format: Article
Language:English
Subjects:
Adult
Antibodies, Protozoan - blood
Antigens, Protozoan - immunology
Biological and medical sciences
Cell Proliferation - drug effects
Enzyme-Linked Immunosorbent Assay
General aspects
Histidine-rich protein II
Human protozoal diseases
Humans
IFN-γ
IL-4
Immunity, Cellular - immunology
Infectious diseases
Interferon-gamma - biosynthesis
Interleukin-4 - biosynthesis
Leukocytes, Mononuclear - drug effects
Malaria
Malaria, Falciparum - immunology
Medical sciences
Merozoite surface protein 1
Merozoite Surface Protein 1 - immunology
Parasitic diseases
Plasmodium falciparum
Plasmodium falciparum - immunology
Proliferation
Protozoal diseases
Protozoan Proteins - immunology
T-Lymphocytes - immunology
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Summary:The precise function of Plasmodium falciparum histidine-rich protein II (HRPII) is not known, but in vitro studies have indicated its immunomodulatory function. The host immune response to HRPII was measured and compared with the response to P. falciparum merozoite surface protein 1 (MSP1) in four groups of study subjects (healthy malaria-naïve adults, uncomplicated malaria patients, asymptomatic parasite carriers and aparasitemic endemic adults; n = 15 in each group). Serum antibody concentrations, lymphocyte proliferation and IFN-( and IL-4 responses were significantly higher with MSP1 than with HRPII stimulation in all three malaria-exposed groups ( P < 0.001), suggesting a strong immunomodulatory role for HRPII.
ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2010.01.002