Prevalence of viral hepatitis and molecular analysis of HBV among voluntary blood donors in west Iran

To determine the prevalence of viral hepatitis infection and hepatitis B virus (HBV) molecular characterization, 11,200 blood donors from citizens of Shahrekord (a city located in west of Iran) were investigated. Results showed HBsAg-positive in 1.78% of persons (n=200), anti-HDV-positive in 3% of H...

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Bibliographic Details
Published in:The New microbiologica 2009-04, Vol.32 (2), p.193-198
Main Authors: Doosti, Abbas, Amini-Bavil-Olyaee, Samad, Tajbakhsh, Elaheh, Adeli, Ahmad, Mahboudi, Fereidoun
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood Donors
DNA, Viral - analysis
Drug Resistance, Viral - genetics
Female
Genes, pol - genetics
Hepacivirus - isolation & purification
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - isolation & purification
Hepatitis Delta Virus - isolation & purification
Hepatitis, Viral, Human - blood
Hepatitis, Viral, Human - epidemiology
Hepatitis, Viral, Human - virology
Humans
Iran - epidemiology
Male
Middle Aged
Phylogeny
Seroepidemiologic Studies
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Summary:To determine the prevalence of viral hepatitis infection and hepatitis B virus (HBV) molecular characterization, 11,200 blood donors from citizens of Shahrekord (a city located in west of Iran) were investigated. Results showed HBsAg-positive in 1.78% of persons (n=200), anti-HDV-positive in 3% of HBsAg-positive cases (n=6) and anti-HCV-positive in 0.67% of donors (n=76). HBV phylogenetic analysis disclosed HBV genotype D, sub-genotype D1, and subtype ayw2. Amino acid mapping of the HBV pol region revealed various HBV drug-resistance mutations though donors had no antiviral therapy. In conclusion, this study demonstrated notable viral hepatitis seroprevalence rate in blood donors in west of Iran.
ISSN:1121-7138