Development of a degradable composite for orthopaedic use: mechanical evaluation of an hydroxyapatite-polyhydroxybutyrate composite material

This study evaluates the mechanical properties of a composite material comprising polyhydroxybutyrate with hydroxyapatite added in proportions varying from 0 to 50%. Among the three methods of production, injection moulding was found to result in the most satisfactory mechanical properties. The tens...

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Bibliographic Details
Published in:Biomaterials 1993-08, Vol.14 (10), p.793-796
Main Authors: Boeree, N.R., Dove, J., Cooper, J.J., Knowles, J., Hastings, G.W.
Format: Article
Language:English
Subjects:
Biocompatible Materials
Biodegradation, Environmental
Biological and medical sciences
Biomechanical Phenomena
bone formation
Composite Resins
Durapatite
Elasticity
Humans
Hydroxyapatite
Hydroxybutyrates
Medical sciences
Microscopy, Electron, Scanning
Microspheres
orthopaedic polymer
Orthopedic surgery
Orthopedics
polyhydroxybutyrate
Polymers
Prostheses and Implants
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tensile Strength
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Summary:This study evaluates the mechanical properties of a composite material comprising polyhydroxybutyrate with hydroxyapatite added in proportions varying from 0 to 50%. Among the three methods of production, injection moulding was found to result in the most satisfactory mechanical properties. The tensile and compressive strength and the modulus of elasticity of composite produced in this way fell within the range for fresh human bone from different anatomical sites. With the additional advantages of biocompatability, biodegradability and the potential for piezoelectric stimulation of new local bone formation, it was concluded that the injection-moulded composite material has considerable potential for use in orthopaedic surgery, both as a material to construct certain orthopaedic implants and as an alternative to corticocancellous bone graft.
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(93)90046-5