Resistance to Ehrlich ascites tumor in a strain of dystrophic mice

Ehrlich ascites tumor grows in almost any mouse host. We have found a strain of dystrophic mice to be strongly resistant to Ehrlich ascites tumor. Mice of the dystrophic strain survived injection of Ehrlich Ascites tumor cells that had just been passaged through either dystrophic mice or C57BL X DBA...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1979-06, Vol.39 (6 Pt 1), p.2139-2140
Main Authors: Carry, P J, Prescott, D M, Ogilvie, G K
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Ehrlich Tumor - immunology
Female
Graft Rejection
Histocompatibility Antigens
Male
Mice
Mice, Inbred Strains
Muscular Dystrophies - genetics
Muscular Dystrophies - immunology
Neoplasm Transplantation
Species Specificity
Transplantation, Homologous
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Summary:Ehrlich ascites tumor grows in almost any mouse host. We have found a strain of dystrophic mice to be strongly resistant to Ehrlich ascites tumor. Mice of the dystrophic strain survived injection of Ehrlich Ascites tumor cells that had just been passaged through either dystrophic mice or C57BL X DBA/2 F1, (hereafter known as BD2F1) mice. However, most of the dystrophic mice died when they were given injections of Ehrlich ascites tumor cells that had just been passaged through Swiss white mice. All Swiss white and BD2F1 mice died when they were inoculated with Ehrlich ascites tumor cells, regardless of the type of mouse through which the Ehrlich ascites tumor cells had just been passaged. In some dystrophic mice, the tumor grew to a palpabale size and then disappeared. This provided the opportunity to passage the tumor from one dystrophic mouse to another and thereby to demonstrate resistance in the dystrophic mice to tumor that had grown previously in dystrophic mice. There was no detectable difference in the rate of tumor growth in either Swiss white or BD2F1 mice.
ISSN:0008-5472