Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis

Objective To investigate the effect of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis (SAP). Methods Rats were randomly divided into sham-operated, model control, and dexamethasone-treated groups. At 3, 6, and 12 h after operati...

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Bibliographic Details
Published in:Inflammation research 2010, Vol.59 (1), p.31-39
Main Authors: Xiping, Zhang, Jun, Fu, Jie, Zhang, Bingyan, Yu, Jing, Ma, Wei, Zhu, Jing, Ye, Penghui, Jia, Wenqin, Yuan, Ninnin, Zhou, Jiao, He
Format: Article
Language:English
Subjects:
Acute Disease
Allergology
Animals
Anti-Inflammatory Agents - therapeutic use
Biomedical and Life Sciences
Biomedicine
Dermatology
Dexamethasone - therapeutic use
Disease Models, Animal
Immunology
Kidney - metabolism
Kidney - pathology
Liver - metabolism
Liver - pathology
Lung - metabolism
Lung - pathology
Male
Neurology
Original Research Paper
P-Selectin - metabolism
Pancreas - metabolism
Pancreas - pathology
Pancreatitis - drug therapy
Pancreatitis - metabolism
Pancreatitis - pathology
Pharmacology/Toxicology
Rats
Rats, Sprague-Dawley
Rheumatology
Severity of Illness Index
Spleen - metabolism
Spleen - pathology
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Summary:Objective To investigate the effect of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis (SAP). Methods Rats were randomly divided into sham-operated, model control, and dexamethasone-treated groups. At 3, 6, and 12 h after operation, the expression levels of P-selectin protein in one-third of the rats in each group were observed. Results In the treated group, the expression levels of P-selectin protein in the pancreas head (at 6 h), lung (at 12 h), liver (at 3 h), and spleen (at 6 and 12 h) were significantly lower than those in the model control group (P < 0.05). Additionally, the products of the staining intensity and positive rate of P-selectin protein in liver (at 3 h), lung (at 6 and 12 h), and spleen (at 12 h) in the treated group were significantly lower than those in the model control group (P < 0.05). Conclusions Dexamethasone can inhibit P-selectin protein expression in multiple organs of SAP rats.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-009-0067-x