Reliability of salivary cortisol assessments in cocaine dependent individuals

The aim of this study was to assess the reliability of salivary cortisol as a measure of hypothalmic–pituitary–adrenal (HPA) axis function in cocaine dependent individuals. Saliva and total plasma samples were collected from 49 abusers on 3 testing days in the morning, across eight time points per d...

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Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2006-09, Vol.20 (5), p.650-655
Main Authors: Fox, H. C., Wilker, E. H., Kreek, M. J., Sinha, R.
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Adult
Biological and medical sciences
Blood Specimen Collection
Cocaine
Cocaine-Related Disorders - diagnosis
Cocaine-Related Disorders - metabolism
Cortisol
Drug addictions
Drug addicts
Evaluation
Female
Hormones
Humans
Hydrocortisone
Hydrocortisone - analysis
Hydrocortisone - blood
Hydrocortisone - metabolism
Hypothalamic-pituitary-adrenal axis
Hypothalamo-Hypophyseal System - physiology
Male
Medical sciences
Menstrual Cycle - metabolism
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Pituitary
Psychiatric Status Rating Scales
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Reproducibility of Results
Saliva
Saliva - chemistry
Sex Characteristics
Specimen Handling
Testing
Toxicology
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Summary:The aim of this study was to assess the reliability of salivary cortisol as a measure of hypothalmic–pituitary–adrenal (HPA) axis function in cocaine dependent individuals. Saliva and total plasma samples were collected from 49 abusers on 3 testing days in the morning, across eight time points per day. Significant associations between saliva and plasma cortisol were observed across all time points collapsed across 3 days in both men and women. These moderately significant correlations suggest that salivary measurements represent a stable, non-invasive and broad indicator of HPA axis functioning in cocaine dependent individuals.
ISSN:0269-8811
1461-7285
DOI:10.1177/0269881106063474