Downstream processing of recombinant proteins from transgenic feedstock

The search for inexpensive production systems capable of producing large quantities of recombinant protein has resulted in the development of new technology platforms based on transgenic plants and animals. Over the past decade, these transgenic systems have been used to produce several products and...

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Bibliographic Details
Published in:Current opinion in biotechnology 2004-10, Vol.15 (5), p.479-486
Main Authors: Nikolov, Zivko L, Woodard, Susan L
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified - metabolism
Biotechnology - methods
Cost-benefit analysis
Feeds
Plants, Genetically Modified - metabolism
Proteins
Q1
Recombinant Proteins - biosynthesis
Recombinant Proteins - therapeutic use
Reviews
Transgenic animals
Transgenic plants
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Summary:The search for inexpensive production systems capable of producing large quantities of recombinant protein has resulted in the development of new technology platforms based on transgenic plants and animals. Over the past decade, these transgenic systems have been used to produce several products and potential therapeutic proteins. Improvements continue to be made, not only in how the proteins are expressed but also in how the end products are obtained. As improvements in expression are realized, cost-saving measures will increasingly focus on downstream processing.
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2004.08.006