Glycyrrhetinic Acid Induces Anoikis-Like Death and Cytoskeletal Disruption in the Central Nervous System Tumorigenic Cells

We analyzed the effects of glycyrrhetinic acid (GA), a licorice compound, on the induction of anoikis-like death and cytoskeletal disruption in the central nervous system (CNS) tumorigenic cells. GA was cytotoxic in time- and dose-dependent manners, and the tumorigenic cells shed floating cells upon...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2010/02/01, Vol.33(2), pp.321-324
Main Authors: Yamaguchi, Hideaki, Kidachi, Yumi, Kamiie, Katsuyoshi, Noshita, Toshiro, Umetsu, Hironori, Ryoyama, Kazuo
Format: Article
Language:English
Subjects:
Animals
Anoikis - drug effects
Anoikis - physiology
Cell Death - drug effects
Cell Death - physiology
Central Nervous System Neoplasms - drug therapy
Central Nervous System Neoplasms - pathology
Cytoskeleton - drug effects
Cytoskeleton - pathology
Dose-Response Relationship, Drug
glycyrrhetinic acid
Glycyrrhetinic Acid - pharmacology
Glycyrrhetinic Acid - therapeutic use
Glycyrrhiza glabra
human c-Ha-ras mouse c-myc cotransfected highly metastatic serum-free mouse embryo-1
Humans
licorice
Mice
Mice, Inbred BALB C
tumor
Tumor Cells, Cultured
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Summary:We analyzed the effects of glycyrrhetinic acid (GA), a licorice compound, on the induction of anoikis-like death and cytoskeletal disruption in the central nervous system (CNS) tumorigenic cells. GA was cytotoxic in time- and dose-dependent manners, and the tumorigenic cells shed floating cells upon the GA treatment and even some of the adherent cells were easily detached from the fibronectin-coated culture dish by gentle shaking and aspiration. Reculture of the detached cells revealed that the longer the duration of GA exposure, the less the number of the proliferatable cells. These results indicate that GA perturbs cell adhesion and induces anoikis-like cell death. Further, GA also induced morphologic changes and disturbed cytoskeletal proteins.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.33.321