Evaluation of C-reactive protein, interleukin-6, and procalcitonin levels in allogeneic hematopoietic stem cell recipients

:  Background: Prompt detection of transplant‐related complications (TRC) as infections, acute graft‐versus‐host disease (aGVHD), microangiopathic hemolytic anemia, or veno‐occlusive disease following allogeneic hematopoietic stem cell transplantation (HSCT) is essential.Patients and methods: We con...

Full description

Saved in:
Bibliographic Details
Published in:European journal of haematology 2006-02, Vol.76 (2), p.93-101
Main Authors: Pihusch, Markus, Pihusch, Rudolf, Fraunberger, Peter, Pihusch, Verena, Andreesen, Reinhard, Kolb, Hans-Jochem, Holler, Ernst
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
C-reactive protein
C-Reactive Protein - metabolism
Calcitonin - metabolism
Calcitonin Gene-Related Peptide
Female
hematopoietic stem cell transplantation
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
interleukin-6
Interleukin-6 - metabolism
Male
Middle Aged
procalcitonin
Protein Precursors - metabolism
Transplantation, Homologous
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary::  Background: Prompt detection of transplant‐related complications (TRC) as infections, acute graft‐versus‐host disease (aGVHD), microangiopathic hemolytic anemia, or veno‐occlusive disease following allogeneic hematopoietic stem cell transplantation (HSCT) is essential.Patients and methods: We conducted a prospective trial on clinical significance of C‐reactive protein (CRP), interleukin‐6 (IL‐6) and procalcitonin (PCT) serum levels in TRC. A total of 350 stem cell recipients were admitted. CRP, IL‐6 and PCT were analyzed prior to conditioning and weekly until 8 wk after HSCT. TRC were recorded weekly throughout the study.Results: CRP (4.4 mg/dL vs. 12.8 mg/dL; P 
ISSN:0902-4441
1600-0609
DOI:10.1111/j.0902-4441.2005.00568.x