The microbiology of chronic osteomyelitis: Prevalence of resistance to common empirical anti-microbial regimens

Summary Objectives This study describes the microbiological spectrum of chronic osteomyelitis and so guides the choice of empirical antibiotics for this condition. Methods We performed a prospective review of a 166 prospective patient series of chronic osteomyelitis from Oxford, UK in which a standa...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infection 2010-05, Vol.60 (5), p.338-343
Main Authors: Sheehy, S.H, Atkins, B.A, Bejon, P, Byren, I, Wyllie, D, Athanasou, N.A, Berendt, A.R, McNally, M.A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacteria - classification
Bacteria - drug effects
Bacteria - isolation & purification
Bacterial arthritis and osteitis
Bacterial diseases
Bacterial Infections - epidemiology
Bacterial Infections - microbiology
Biological and medical sciences
Chronic Disease - epidemiology
Drug Resistance, Bacterial
Female
General aspects
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Osteomyelitis
Osteomyelitis - microbiology
Prevalence
Prospective Studies
Staphylococcus aureus
United Kingdom - epidemiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Objectives This study describes the microbiological spectrum of chronic osteomyelitis and so guides the choice of empirical antibiotics for this condition. Methods We performed a prospective review of a 166 prospective patient series of chronic osteomyelitis from Oxford, UK in which a standardised surgical sampling protocol was used. Results Staphylococcus aureus was most commonly isolated (32%) amongst a wide range of organisms including gram negative bacilli, anaerobes and coagulase negative staphylococci. Low grade pathogens were not confined to patients with a history of metalwork, a high proportion of cases were polymicrobial (29%) and culture negative cases were common (28%). No clear predictors of causative organism could be established. Many isolates were found to be resistant to commonly used empirical anti-microbial regimens. Conclusions The wide range of causative organisms and degree of resistance to commonly used anti-microbials supports the importance of extensive intra-operative sampling and provides important information to guide clinicians' choice of empirical antibiotics.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2010.03.006