Improved sensitivity of the BTPABA pancreatic function test in animals with meals of raw egg white

An indirect exocrine pancreatic function test (PFT) which measures the ability of a test to hydrolyze a chymotrypsin-labile peptide (N-benzoyl-L-tyrosyl-PABA), was carried out in rats and swine with simulated partial exocrine pancreatic insufficiency. When spray-dried egg white (SDEW), which contain...

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Bibliographic Details
Published in:Digestive diseases and sciences 1979-03, Vol.24 (3), p.214-216
Main Authors: Imondi, A R, Wolgemuth, R L
Format: Article
Language:English
Subjects:
4-Aminobenzoic Acid - metabolism
4-Aminobenzoic Acid - pharmacology
4-Aminobenzoic Acid - urine
Amines - urine
Aminobenzoates - urine
Animals
Caseins - pharmacology
Chymotrypsin - antagonists & inhibitors
Chymotrypsin - metabolism
Diet
Dogs
Egg White
Female
Male
Methods
Pancreas - metabolism
Pancreas - physiology
Pancreas - physiopathology
Pancreatic Diseases - diagnosis
Pancreatic Diseases - metabolism
Pancreatic Diseases - physiopathology
Pancreatin - pharmacology
Peptides - pharmacology
Rats
Swine
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Summary:An indirect exocrine pancreatic function test (PFT) which measures the ability of a test to hydrolyze a chymotrypsin-labile peptide (N-benzoyl-L-tyrosyl-PABA), was carried out in rats and swine with simulated partial exocrine pancreatic insufficiency. When spray-dried egg white (SDEW), which contains an inhibitor of chymotrypsin, was administered as a test meal with the PFT, the degree of pancreatic insufficiency was more pronounced. The results suggest that SDEW or raw egg while may be useful as a test meal to be given in conjunction with the PFT in humans in order to accentuate moderate degrees of pancreatic insufficiency and improve the sensitivity of this indirect test of pancreatic function.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01308432