Serum interleukin-6 and C-reactive protein are markedly elevated in acute decompensated heart failure patients with left ventricular systolic dysfunction

Cytokines play important roles in heart failure (HF). We examined whether cytokine levels are different in acute decompensated heart failure (ADHF) patients between with left ventricular systolic dysfunction (LVSDF) and with preserved LV ejection function (PLVEF). We studied 81 HF patients who were...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2010-03, Vol.49 (3), p.264-268
Main Authors: Matsumoto, Mika, Tsujino, Takeshi, Lee-Kawabata, Masaaki, Naito, Yoshiro, Sakoda, Tsuyoshi, Ohyanagi, Mitsumasa, Masuyama, Tohru
Format: Article
Language:English
Subjects:
Acute decompensated heart failure
Aged
Aged, 80 and over
C-Reactive Protein - metabolism
Cytokines - blood
Female
Heart Failure - blood
Heart Failure - physiopathology
Highly sensitive C-reactive protein
Humans
Interleukin-18 - blood
Interleukin-6
Interleukin-6 - blood
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Tumor Necrosis Factor-alpha - blood
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - physiopathology
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Summary:Cytokines play important roles in heart failure (HF). We examined whether cytokine levels are different in acute decompensated heart failure (ADHF) patients between with left ventricular systolic dysfunction (LVSDF) and with preserved LV ejection function (PLVEF). We studied 81 HF patients who were admitted to our hospital with acute decompensation. They were divided into two groups: LVSDF (LVEF) < 45% and PLVEF (LVEF ⩾ 45%). Serum interleukin-6 (IL-6), highly sensitive C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), and IL-18 and plasma brain natriuretic peptide (BNP) were measured on admission and at discharge. On admission, IL-6 and hsCRP were higher in LVSDF than in PLVEF. IL-6 and hsCRP decreased after treatment in LVSDF, but not in PLVEF, while plasma BNP levels decreased in both HF with treatment. There was no difference in TNF-α or in IL-18 level between LVSDF and PLVEF, and they did not change after treatment in either group. In conclusion, cytokine profiles were different in ADHF between those with LVSDF and PLVEF. Activation of IL-6–hsCRP pathway may play a specific role in ADHF with LVSDF.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2009.11.006