Two new cerebrosides from the pollen of Typha angustifolia

Two new cerebrosides, 1- O-(β- d-glucopyranosyloxy)-(2 S,3 S,4 R,8 Z)-2-[(2′ R)-2′-hydroxytricosanoylamino]-8-nonadecene-3,4-diol ( 1) and 1- O-(β- d-glucopyranosyloxy)-(2 S,3 R,4 E,8 Z)-2-[(2′ R)-2′-hydroxynonadecanoylamino]-4,13-nonadecene-3-diol ( 2), were isolated from the pollen of Typha angust...

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Bibliographic Details
Published in:Fitoterapia 2010-04, Vol.81 (3), p.196-199
Main Authors: Tao, Wei-Wei, Yang, Nian-Yun, Liu, Li, Duan, Jin-Ao, Wu, De-Kang, Qian, Da-Wei, Tang, Yu-Ping
Format: Article
Language:English
Subjects:
Cerebroside
Typha
Typha angustifolia
Typhaceae
Vascular smooth muscle cell (VSMCs)
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Summary:Two new cerebrosides, 1- O-(β- d-glucopyranosyloxy)-(2 S,3 S,4 R,8 Z)-2-[(2′ R)-2′-hydroxytricosanoylamino]-8-nonadecene-3,4-diol ( 1) and 1- O-(β- d-glucopyranosyloxy)-(2 S,3 R,4 E,8 Z)-2-[(2′ R)-2′-hydroxynonadecanoylamino]-4,13-nonadecene-3-diol ( 2), were isolated from the pollen of Typha angustifolia. Their structures were elucidated by chemical and spectral means. This is the first report on the occurrence of cerebroside in Typha (Typhaceae). Compounds 1 and 2 exhibited effect on the proliferation of cultured vascular smooth muscle cell (VSMCs) induced by fatal bovine serum (FBS). Two new cerebrosides, 1- O-(β- d-glucopyranosyloxy)-(2 S,3 S,4 R,8 Z)-2-[(2′ R)-2′-hydroxytricosanoylamino]-8-nonadecene-3,4-diol ( 1) and 1- O-(β- d-glucopyranosyloxy)-(2 S,3 R,4 E,8 Z)-2-[(2′ R)-2′-hydroxynonadecanoylamino]-4,13-nonadecene-3-diol ( 2), were isolated from the pollen of Typha angustifolia. Compounds 1 and 2 exhibited effect on the proliferation of cultured vascular smooth muscle cell (VSMCs) induced by fatal bovine serum (FBS). [Display omitted]
ISSN:0367-326X
DOI:10.1016/j.fitote.2009.08.026