Synthesis of a proposed thymic factor

Less than Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, a proposed serum thymic factor, has been synthesized. The protected precursor, less than Glu-Ala-Lys(i-Noc)-ser(Bzl)-Gln-Gly-Gly-Ser(Bzl)-Asn, was prepared by a combination of solid phase and solution methods. The benzyl blocking groups were removed by...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1979-05, Vol.22 (5), p.586-588
Main Authors: Strachan, Robert G, Paleveda, William J, Bergstrand, Susan J, Nutt, Ruth F, Holly, Frederick W, Veber, Daniel F
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Methods
Oligopeptides - chemical synthesis
Thymus Hormones - chemical synthesis
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Summary:Less than Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, a proposed serum thymic factor, has been synthesized. The protected precursor, less than Glu-Ala-Lys(i-Noc)-ser(Bzl)-Gln-Gly-Gly-Ser(Bzl)-Asn, was prepared by a combination of solid phase and solution methods. The benzyl blocking groups were removed by HF and the i-Noc blocking group was removed by catalytic hydrogenation.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00191a026