Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia

Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during ea...

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Bibliographic Details
Published in:International journal of hematology 2009-11, Vol.90 (4), p.483-485
Main Authors: Horino, Satoshi, Rikiishi, Takeshi, Niizuma, Hidetaka, Abe, Hiroshi, Watanabe, Yuko, Onuma, Masaei, Hoshi, Yoshiyuki, Sasahara, Yoji, Yoshinari, Miyako, Kazama, Takuro, Hayashi, Yutaka, Kumaki, Satoru, Tsuchiya, Shigeru
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Case Report
Child
Chronic Disease
Female
Hematologic and hematopoietic diseases
Hematology
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Medicine
Medicine & Public Health
Oncology
Platelet diseases and coagulopathies
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Purpura, Thrombocytopenic, Idiopathic - complications
Purpura, Thrombocytopenic, Idiopathic - drug therapy
Purpura, Thrombocytopenic, Idiopathic - surgery
Splenectomy
Treatment Outcome
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Summary:Immune thrombocytopenic purpura (ITP) has been associated with several hematologic malignancies such as Hodgkin and non-Hodgkin lymphomas and chronic lymphocytic leukemia, but it is rare in children with acute lymphoblastic leukemia (ALL). Here, we report a 7-year-old girl with chronic ITP during early intensive phase of chemotherapy for ALL. She underwent splenectomy because thrombocytopenia had persisted even after treatment with intravenous immunoglobulin (IVIG), steroids, vincristine, rituximab, and anti-D antibody. After splenectomy, her platelet count had recovered, and maintenance therapy could be resumed with a support of IVIG. To our knowledge, this is the first child case of chronic ITP during chemotherapy for ALL and splenectomy was effective in this patient.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-009-0424-0