Taking vitamin D with the largest meal improves absorption and results in higher serum levels of 25‐hydroxyvitamin D

Many patients treated for vitamin D deficiency fail to achieve an adequate serum level of 25‐hydroxyvitamin D [25(OH)D] despite high doses of ergo‐ or cholecalciferol. The objective of this study was to determine whether administration of vitamin D supplement with the largest meal of the day would i...

Full description

Saved in:
Bibliographic Details
Published in:Journal of bone and mineral research 2010-04, Vol.25 (4), p.928-930
Main Authors: Mulligan, Guy B, Licata, Angelo
Format: Article
Language:English
Subjects:
Absorption
administration
Administration, Oral
Aged
Biological and medical sciences
Cohort Studies
deficiency
diet
Dietary Supplements
Drug Administration Schedule
Female
Food
Fundamental and applied biological sciences. Psychology
Humans
Male
Middle Aged
Prospective Studies
Skeleton and joints
Vertebrates: osteoarticular system, musculoskeletal system
vitamin D
Vitamin D - administration & dosage
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D - pharmacokinetics
Vitamin D Deficiency - drug therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Many patients treated for vitamin D deficiency fail to achieve an adequate serum level of 25‐hydroxyvitamin D [25(OH)D] despite high doses of ergo‐ or cholecalciferol. The objective of this study was to determine whether administration of vitamin D supplement with the largest meal of the day would improve absorption and increase serum levels of 25(OH)D. This was a prospective cohort study in an ambulatory tertiary‐care referral center. Patients seen at the Cleveland Clinic Foundation Bone Clinic for the treatment of vitamin D deficiency who were not responding to treatment make up the stugy group. Subjects were instructed to take their usual vitamin D supplement with the largest meal of the day. The main outcome measure was the serum 259(OH)D level after 2 to 3 months. Seventeen patients were analyzed. The mean age (±SD) and sex (F/M) ratio were 64.5 ± 11.0 years and 13 females and 4 males, respectively. The dose of 25(OH)D ranged from 1000 to 50,000 IU daily. The mean baseline serum 25(OH)D level (±SD) was 30.5 ± 4.7 ng/mL (range 21.6 to 38.8 ng/mL). The mean serum 25(OH)D level after diet modification (±SD) was 47.2 ± 10.9 ng/mL (range 34.7 to 74.0 ng/mL, p 
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.67